A 12-lead ECG can be used to determine the coronary artery that is most likely affected by an ischemic event. Leads II, III, and aVF provide a view of the right coronary artery. The purpose of this study was to detect acute myocardial infarction in the 12–lead ECG with artificial neural networks. In a myocardial infarction transmural ischemia develops. In the first hours and days after the onset of a myocardial infarction, several changes can be observed on the ECG. First, large peaked T waves (or hyperacute T waves), then ST elevation, then negative T waves and finally pathologic Q waves develop.